Selected Publications

Jerby-Arnon L*, Neftel C*, Shore M, McBride MJ, Haas B, Izar B, Volorio A, Boulay G, Cironi L, Richman AR, Broye LC, Gurski JM, Luo CC, Mylvaganam R, Nguyen L, Mei S, Melms J, Georgescu C, Nielsen P, Chebib I, Cote G, Choy E, Letovanec I, Cherix S, Wagle N, Sorger PK, Haynes AB, Mullen JT, Stamenkovic I, Rivera MN, Kadoch C, Rozenblatt-Rosen O, Suvà ML**, Riggi N**, Regev**. Opposing genetic and immune forces shape oncogenic programs in Synovial Sarcoma. Nature Medicine in press.

Boulay G*, Cironi L*, Garcia S, Rengarajan S, Xing Y-H, Lee L, Awad ME, Naigles B, Iyer S, Broye LC, Keskin T, Cauderay A, Fusco C, Letovanec I, Chebib I, Nielsen GP, Tercier S, Cherix S, Nguyen-Ngoc T, Cote G, Choy E, Provero P, Suvà ML, Rivera MN**, Stamenkovic I** and Riggi N**. The chromatin landscape of primary synovial sarcoma organoids is linked to specific epigenetic mechanisms and dependencies. Life Science Alliance in press.

Boulay G, Volorio A, Iyer S, Broye LC, Stamenkovic I, Riggi N**, Rivera MN**. Epigenome editing of microsatellite repeats defines tumor-specific enhancer functions and dependencies. Genes and Dev. 2018 Aug 1;32(15-16):1008-1019. doi: 10.1101/gad.315192.118.

Torsello M*, Boulay G*, Cornaz S*, Bakaric A, Keskin T, Martin P, Volorio A, Iyer S, Kulkarni A, Letovanec I, Cherix S, Cote GM, Choy E, Digklia A, Montemurro M, Chebib I, Nielsen GP, Carcaboso AM, Mora J, Renella R, Suvà ML, Provero P, Rivera MN**, Riggi N** and Stamenkovic I**. LIN28B underlies the pathogenesis and therapeutic sensitivity of a subclass of Ewing sarcoma. Cell Rep. 2020 Apr 14;31(2):107539. doi: 10.1016/j.celrep.2020.107539.PMID: 3229444

Neftel C*, Laffy J*, Filbin MG*, Hara T*, Shore ME, Rahme GJ, Richman AR, Silverbush D, Shaw ML, Hebert CM, Dewitt J, Gritsch S, Perez L, L. Castro NG, Lan X, Druck N, Rodman C, Dionne D, Kaplan A, Bertalan MS, Small J, Pelton K, Becker S, Bonal D, Nguyen QD, Servis RL, Brasti PK, Batchelor TT, Stemmer-Rachamimov A, Martinez-Lage M, Frosch MP, Stamenkovic I, Riggi N, Rheinbay E, Monje M, Rozenblatt-Rosen O, Cahill DP, Patel AP, Hunter T, Verma IM, Ligon KL, Louis DN, Regev A, Bernstein BE, Tirosh I**, Suvà ML** An integrative model of cellular states, plasticity and genetics for glioblastoma. Cell. 2019 Jul 9. pii: S0092-8674(19)30687-7. doi: 10.1016/j.cell.2019.06.024.

Riggi N*, Knoechel B*, Gillespie S*, Rheinbay E, Boulay G, Suvà ML, Rossetti NE, Boonseng WE, Oksuz O, Cook EB, Formey De Saint Louvent A, Patel A, Thapar V, Deshpande V, Ting DT, Hornicek FJ, Nielsen GP, Stamenkovic I, Aryee M, Bernstein BE and Rivera MN. EWS-FLI1 utilizes divergent chromatin remodeling mechanisms to directly activate or repress enhancer elements in Ewing sarcoma.Cancer Cell. 2014 Nov 10;26(5):668-81.

Suvà ML*, Riggi N* and Bernstein BE. Epigenetic reprogramming in cancer. Science. 2013 Mar 29;339(6127):1567-70.